The Turn off Microsoft Defender Antivirus Group Policy setting or its equivalent registry setting DisableAntiSpyware = 1 would require rebooting the computer.It takes several mouse clicks to turn off/on the Windows Defender real-time protection through the user interface.You may prefer a single-click shortcut or script solution because of the following reasons: There are times when you need to temporarily disable your Windows Defender real-time protection on your test (non-production) systems and switch it back on after a few minutes. ![]() ![]() ![]() Almost every aspect of Windows Defender can be managed or automated using the MpCmdrun.exe command-line tool and PowerShell cmdlets.
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